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CYP2D6 phenotype explains reported yohimbine concentrations in four severe acute intoxications.

Archives of toxicology - 1 Aug 2021

Mueller-Schoell Anna, Michelet Robin, Weinelt Ferdinand, Kloft Charlotte, Mikus Gerd

Abstract excerpt

The indole alkaloid yohimbine is an alpha-2 receptor antagonist used for its sympathomimetic effects. Several cases of yohimbine intoxication have been reported and the most recent one involved four individuals taking a yohimbine-containing drug powder. All individuals developed severe intoxication symptoms and were admitted to the hospital. Even though all individuals were assumed to have taken the same dose of...

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Identifiers

PMID: 34027562
DOI: 10.1007/s00204-021-03082-4
PMCID: PMC8298364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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