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Article

Oral Yohimbine as a New Probe Drug to Predict CYP2D6 Activity: Results of a Fixed-Sequence Phase I Trial.

Clinical pharmacokinetics - 1 Jul 2020

Vay Manuela, Meyer Marleen Julia, Blank Antje, Skopp Gisela, Rose Peter, Tzvetkov Mladen Vassilev, Mikus Gerd

Abstract excerpt

OBJECTIVE: Yohimbine pharmacokinetics were determined after oral administration of a single oral dose of yohimbine 5 mg and a microdose of yohimbine 50 µg in relation to different cytochrome P450 (CYP) 2D6 genotypes. The CYP2D6 inhibitor paroxetine was used to investigate the influence on yohimbine pharmacokinetics. Microdosed midazolam was applied to evaluate a possible impact of yohimbine on CYP3A activity and...

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Identifiers

PMID: 32060866
DOI: 10.1007/s40262-020-00862-6
PMCID: PMC7329762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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