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Article

Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine.

Circulation. Cardiovascular genetics - 1 Apr 2011

Kurnik Daniel, Muszkat Mordechai, Li Chun, Sofowora Gbenga G, Friedman Eitan A, Scheinin Mika, Wood Alastair J J, Stein C Michael

Abstract excerpt

BACKGROUND: α(2A)-Adrenoceptors (α(2A)-ARs) have important roles in sympathetic cardiovascular regulation. Variants of ADRA2A affect gene transcription and expression and are associated with insulin release and risk for type 2 diabetes. We examined whether ADRA2A variants are also associated with cardiovascular responses to the selective α(2)-AR-agonist dexmedetomidine. METHODS AND RESULTS: Seventy-three healthy...

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Identifiers

PMID: 21325151
DOI: 10.1161/CIRCGENETICS.110.957662
PMCID: PMC3080459

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