Article
Pharmacogenetic explanation for excessive beta-blockade following timolol eye drops. Potential for oral-ophthalmic drug interaction.
JAMA - 1 Jan 2000
Edeki T I, He H, Wood A J
Abstract excerpt
OBJECTIVE: To determine whether the effects of topically administered timolol in an individual would be dependent on the presence or absence in that individual of the P-450 enzyme CYP2D6 and whether the effects of topically administered timolol would be increased and its metabolism decreased by t...
Topics
- Administration, Oral
- Administration, Topical
- Adrenergic beta-Antagonists
- Adult
- Cross-Over Studies
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Drug Interactions
- Enzyme Inhibitors
- Exercise Test
- Heart Rate
- Humans
- Male
- Mixed Function Oxygenases
- Ophthalmic Solutions
- Phenotype