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Article

Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans.

Pharmacogenetics and genomics - 1 Mar 2005

Neumeister Alexander, Charney Dennis S, Belfer Inna, Geraci Marilla, Holmes Courtney, Sharabi Yehonatan, Alim Tanya, Bonne Omer, Luckenbaugh David A, Manji Husseini, Goldman David, Goldstein David S

Abstract excerpt

OBJECTIVES: alpha2-Adrenoreceptors restrain sympathetic nervous outflows and inhibit release of noradrenaline from sympathetic nerves. In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk. METHODS: Twenty-nine healthy African-Americans genotyped...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15861038
DOI: 10.1097/01213011-200503000-00002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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