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Article

Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response.

Hypertension (Dallas, Tex. : 1979) - 1 Jun 2005

Etzel Jason P, Rana Brinda K, Wen Gen, Parmer Robert J, Schork Nicholas J, O'Connor Daniel T, Insel Paul A

Abstract excerpt

Exaggerated response to alpha2-adrenergic receptor (alpha2-AR) blockade by yohimbine in normotensive subjects is an intermediate phenotype that predicts increased risk for development of hypertension. Here, we assessed the 3 alpha2-AR loci (alpha2A, alpha2B, alpha2C) as candidate genes for their influence on baseline and yohimbine-mediated increase in mean arterial pressure. Because initial results with 173...

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Identifiers

PMID: 15920038
DOI: 10.1161/01.HYP.0000166721.42734.49

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