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Article

Effect of the CYP3A5 genotype on the pharmacokinetics of intravenous midazolam during inhibited and induced metabolic states.

Clinical pharmacology and therapeutics - 1 Aug 2004

Yu Kyung-Sang, Cho Joo-Youn, Jang In-Jin, Hong Kyoung-Seop, Chung Jae-Yong, Kim Jung-Ryul, Lim Hyeong-Seok, Oh Dal-Seok, Yi So-Young, Liu Kwang-Hyeon, Shin Jae-Gook, Shin Sang-Goo

Abstract excerpt

OBJECTIVE: Our objective was to investigate the effect of the CYP3A5 genotype on the systemic clearance of midazolam in constitutive, inhibited, and induced metabolic conditions. METHODS: Nineteen healthy volunteers were grouped with regard to the CYP3A5*3 allele, into homozygous wild-type (CYP3A5*1/*1, n = 6), heterozygous (CYP3A5*1/*3, n = 6), and homozygous variant-type (CYP3A5*3/*3, n = 7) subject groups. The...

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Identifiers

PMID: 15289787
DOI: 10.1016/j.clpt.2004.03.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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