Article
Pharmacokinetics of midazolam and 1'-hydroxymidazolam in Chinese with different CYP3A5 genotypes.
Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2002
Shih Pei-Shan, Huang Jin-Ding
Abstract excerpt
The CYP3A subfamily represents the most abundant cytochrome p450 in the human liver and gastrointestinal tract and plays very important role in xenobiotic metabolism. CYP3A5 is expressed in a relatively small population of whites and Orientals. We recruited 42 Chinese volunteers to determine the genotypes of CYP3A5 by polymerase chain reaction-restriction fragment length polymorphism. Genotype analyses revealed...
Topics
- Area Under Curve
- Asian People
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System
- Genotype
- Humans
- Male
- Midazolam
- Taiwan