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Article

Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers.

Clinical pharmacology and therapeutics - 1 Jun 2005

Chung Jae-Yong, Cho Joo-Youn, Yu Kyung-Sang, Kim Jung-Ryul, Jung Hye-Ryung, Lim Kyoung-Soo, Jang In-Jin, Shin Sang-Goo

Abstract excerpt

OBJECTIVE: Our objective was to investigate the effect of the uridine 5'-diphosphate-glucuronosyltransferase (UGT) 2B15 genetic polymorphism on the pharmacokinetics and pharmacodynamics of lorazepam in basal, inhibited, and induced metabolic states in healthy normal volunteers. METHODS: Twenty-four healthy subjects were enrolled and grouped into UGT2B15*1/*1 or UGT2B15*2/*2 genotype groups. The pharmacokinetic...

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Identifiers

PMID: 15961980
DOI: 10.1016/j.clpt.2005.02.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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