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Article

Effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of alprazolam in healthy subjects.

Clinical pharmacology and therapeutics - 1 Jun 2006

Park Ji-Young, Kim Kyoung-Ah, Park Pil-Whan, Lee Ock-Je, Kang Dong-Kyun, Shon Ji-Hong, Liu Kwang-Hyun, Shin Jae-Gook

Abstract excerpt

OBJECTIVE: Our objective was to evaluate the effect of the CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of alprazolam in healthy volunteers. METHODS: Nineteen healthy male volunteers were divided into 3 groups on the basis of the genetic polymorphism of CYP3A5. The groups comprised subjects with CYP3A5*1/*1 (n=5), CYP3A5*1/*3 (n=7), or CYP3A5*3/*3 (n=7). After a single oral 1-mg dose of...

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PMID: 16765147
DOI: 10.1016/j.clpt.2006.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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