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Article

Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women.

Pharmacogenetics - 1 Oct 2003

Floyd Michael D, Gervasini Guillermo, Masica Andrew L, Mayo Gail, George Alfred L, Bhat Kolari, Kim Richard B, Wilkinson Grant R

Abstract excerpt

CYP3A activity in adults varies between individuals and it has been suggested that this has a genetic basis, possibly related to variant alleles in CYP3A4 and CYP3A5 genes. Accordingly, genotype-phenotype associations were investigated under constitutive and induced conditions. Midazolam's systemic and oral clearances, and the erythromycin breath test (ERBT) were determined in 57 healthy subjects: 23 (11 men, 12...

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PMID: 14515058
DOI: 10.1097/00008571-200310000-00003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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