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Article

In linezolid underexposure, pharmacogenetics matters: The role of CYP3A5.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jul 2021

Cheli Stefania, Fusi Marta, De Silvestri Annalisa, Bonini Igor, Clementi Emilio, Cattaneo Dario, Montrasio Cristina, Baldelli Sara

Abstract excerpt

The exposure to linezolid is characterized by a large inter-individual variability; age, renal dysfunction and body weight explain this variability only to a limited extent and a considerable portion of it remains unexplained; therefore, we decided to investigate the role of individual genetic background focusing in particular on the risk of linezolid underexposure. 191 patients in therapy with linezolid at the...

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Identifiers

PMID: 33940510
DOI: 10.1016/j.biopha.2021.111631

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