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Article

Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression.

Genes & development - 1 Aug 2004

Mao Jian-Hua, To Minh D, Perez-Losada Jesus, Wu Di, Del Rosario Reyno, Balmain Allan

Abstract excerpt

Pten heterozygous (Pten+/-) mice develop increased papilloma numbers and show decreased carcinoma latency time in comparison with controls after skin treatment with dimethyl benzanthracene (DMBA) and tetradecanoyl-phorbol acetate (TPA). H-ras mutation is normally a hallmark of DMBA-TPA-induced skin tumors, but 70% of carcinomas from Pten+/- mice do not exhibit this mutation, and in all cases have lost the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15289454
DOI: 10.1101/gad.1213804
PMCID: PMC517400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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