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Article

Targeted deletion of RasGRP1 impairs skin tumorigenesis.

Carcinogenesis - 1 May 2014

Sharma Amrish, Fonseca Lauren L, Rajani Cynthia, Yanagida Jodi K, Endo Yuka, Cline J Mark, Stone James C, Ji Junfang, Ramos Joe W, Lorenzo Patricia S

Abstract excerpt

Ras is frequently activated in cutaneous squamous cell carcinoma, a prevalent form of skin cancer. However, the pathways that contribute to Ras-induced transformation have not been entirely elucidated. We have previously demonstrated that in transgenic mice, overexpression of the Ras activator RasGRP1 promotes the formation of spontaneous skin tumors and enhances malignant progression in the multistage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24464785
DOI: 10.1093/carcin/bgu016
PMCID: PMC4004207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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