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Article

Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice.

Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2002

You Mingjian James, Castrillon Diego H, Bastian Boris C, O'Hagan Rónán C, Bosenberg Marcus W, Parsons Ramon, Chin Lynda, DePinho Ronald A

Abstract excerpt

Dual inactivation of PTEN and INK4a/ARF tumor suppressor genes is a common feature observed in a broad spectrum of human cancer types. To validate functional collaboration between these genes in tumor suppression, we examined the biological consequences of Pten and/or Ink4a/Arf deficiency in cells and mice. Relative to single mutant controls, Ink4a/Arf-/-Pten+/- mouse embryonic fibroblast cultures exhibited...

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Identifiers

PMID: 11818530
DOI: 10.1073/pnas.022632099
PMCID: PMC122212

Genes

PTEN

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Source receipt: pubmed, retrieved 7 Sept 2026.

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