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Article

DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice.

The Journal of investigative dermatology - 1 Oct 2014

Uhmann Anja, Heß Ina, Frommhold Anke, König Simone, Zabel Sebastian, Nitzki Frauke, Dittmann Kai, Lühder Fred, Christiansen Hans, Reifenberger Julia, Schulz-Schaeffer Walter, Hahn Heidi

Abstract excerpt

The development of basal cell carcinoma (BCC), the most frequently diagnosed tumor among persons with European ancestry, is closely linked to mutations in the Hedgehog (Hh) receptor and tumor suppressor Patched1 (Ptch). Using Ptch(flox/flox)CD4Cre(+/-) mice, in which Ptch was ablated in CD4Cre-expressing cells, we demonstrate that the targeted cells can give rise to BCC after treatment with DMBA...

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Identifiers

PMID: 24662765
DOI: 10.1038/jid.2014.157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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