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Article

Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression.

Genes & development - 15 Mar 2013

Wong Christine E, Yu Jennifer S, Quigley David A, To Minh D, Jen Kuang-Yu, Huang Phillips Y, Del Rosario Reyno, Balmain Allan

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is thought to be an important, possibly essential, component of the process of tumor dissemination and metastasis. About 20%-30% of Hras mutant mouse skin carcinomas induced by chemical initiation/promotion protocols have undergone EMT. Reduced exposure to TPA-induced chronic inflammation causes a dramatic reduction in classical papillomas and squamous cell carcinomas...

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Source

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Identifiers

PMID: 23512660
DOI: 10.1101/gad.210427.112
PMCID: PMC3613613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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