Article
Association of matrix metalloproteinase-1 and -3 promoter polymorphisms with clinical subsets of Norwegian primary sclerosing cholangitis patients.
Journal of hepatology - 1 Aug 2004
Wiencke Kristine, Louka Andrew Sverre, Spurkland Anne, Vatn Morten, Schrumpf Erik, Boberg Kirsten Muri
Abstract excerpt
BACKGROUND/AIMS: Primary sclerosing cholangitis (PSC) is considered an immune mediated liver disease of multifactorial and multigenetic aetiology. Concomitant ulcerative colitis (UC) is seen in many PSC patients, but the pathogenetic link between these disorders is unknown. Due to association with inflammation, fibrosis, and cancer development, the matrix metalloproteinases MMP-1 and MMP-3 are candidate genes for...
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