Article
Association of the tumour necrosis factor alpha -308 but not the interleukin 10 -627 promoter polymorphism with genetic susceptibility to primary sclerosing cholangitis.
Gut - 1 Aug 2001
Mitchell S A, Grove J, Spurkland A, Boberg K M, Fleming K A, Day C P, Schrumpf E, Chapman R W
Abstract excerpt
BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology. Abnormalities in immune regulation and genetic associations suggest that PSC is an immune mediated disease. Several polymorphisms within the tumour necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10) promoter genes have been described which influence expression of these cytokines. This...
Topics
- Adult
- Alleles
- Case-Control Studies
- Cholangitis, Sclerosing
- Confidence Intervals
- Female
- Genotype
- Histocompatibility Testing
- Homozygote
- Humans
- Inflammatory Bowel Diseases
- Interleukin-10
- Male