Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis.

Scandinavian journal of gastroenterology - 1 May 2006

Wiencke Kristine, Boberg Kirsten Muri, Donaldson Peter, Harbo Hanne, Ling Vincent, Schrumpf Erik, Spurkland Anne

Abstract excerpt

OBJECTIVE: Primary sclerosing cholangitis (PSC) is currently thought to be an immune-mediated disease, where both host genes and environmental factors interact. Some of the immunoregulatory genes responsible for individual susceptibility to PSC have been identified. The co-stimulatory receptor gene cluster on chromosome 2q33 encodes both the positive T-cell regulators CD28 and ICOS, and the negative regulator...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Antigens, Differentiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antigens, Differentiation, T-Lymphocyte

Share to CD28 Antigens

Share to Cholangitis, Sclerosing

Share to CTLA-4 Antigen

Share to Inducible T-Cell Co-Stimulator Protein

Share to Norway

Source

Identifiers

PMID: 16638702
DOI: 10.1080/00365520500377870

Genes

CTLA4
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis.PMID 16638702Read ↗

Genetic epidemiology of primary sclerosing cholangitisSemantic proximity Read ↗

Immunogenetics in primary sclerosing cholangitis.Semantic proximity Read ↗

CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population.Semantic proximity Read ↗

Advances and controversies in the pathogenesis and management of primary sclerosing cholangitis.Semantic proximity Read ↗

Genetics of primary sclerosing cholangitis and pathophysiological implications.Semantic proximity Read ↗

Update on primary sclerosing cholangitis genetics.Semantic proximity Read ↗

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.Semantic proximity Read ↗

Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis.Semantic proximity Read ↗

Genome-wide association analysis in primary sclerosing cholangitis.Semantic proximity Read ↗

Genetics in PSC: what do the "risk genes" teach us?Semantic proximity Read ↗

Genetics in primary sclerosing cholangitis.Semantic proximity Read ↗

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.