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Article

Genetic epidemiology of primary sclerosing cholangitis

1 Jan 2007

Abstract excerpt

The aetiology of primary sclerosing cholangitis (PSC) is not known. A more than 80-fold increased risk of PSC among first-degree relatives emphasizes the importance of genetic factors. Genetic associations within the human leukocyte antigen (HLA) complex on chromosome 6p21 were detected in PSC 25 years ago. Subsequent studies have substantiated beyond doubt that one or more genetic variants located within this...

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PMID: 17907284
DOI: 10.3748/wjg.v13.i41.5421

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