Article
MMP-2 is a disease-modifying gene in primary sclerosing cholangitis.
Liver international : official journal of the International Association for the Study of the Liver - 1 Feb 2014
Korkmaz Kerem Sebib, de Rooij Bert-Jan F, van Hoek Bart, Janse Marcel, Coenraad Minneke J, van der Reijden Johan J, Weersma Rinse K, Porte Robert J, Voorneveld Philip W, Baranski Andrzej G, Verspaget Hein W
Abstract excerpt
BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of the bile ducts, frequently necessitating orthotopic liver transplantation (OLT), often accompanied by inflammatory bowel disease (IBD). Matrix metalloproteinases (MMPs) are associated with fibrotic diseases caused by the involvement in tissue remodelling. AIM: To evaluate the contribution of MMP-2 and -9 promoter polymorphisms...
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