Article
Increased risk of primary sclerosing cholangitis and ulcerative colitis in first-degree relatives of patients with primary sclerosing cholangitis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Aug 2008
Bergquist Annika, Montgomery Scott M, Bahmanyar Shahram, Olsson Rolf, Danielsson Ake, Lindgren Stefan, Prytz Hanne, Hultcrantz Rolf, Lööf L A R S, Sandberg-Gertzén Hanna, Almer Sven, Askling Johan, Ehlin Anna, Ekbom Anders
Abstract excerpt
BACKGROUND & AIMS: The importance of genetic factors for the development of primary sclerosing cholangitis (PSC) is incompletely understood. This study assessed the risk of PSC and inflammatory bowel disease (IBD) among first-degree relatives of patients with PSC, compared with the first-degree relatives of a cohort without PSC. METHODS: Subjects from the national Swedish cohort of PSC patients (n = 678) were...
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