Article
Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease.
World journal of gastroenterology - 7 Jun 2007
Meijer Martin J W, Mieremet-Ooms Marij A C, van Hogezand Ruud A, Lamers Cornelis B H W, Hommes Daniel W, Verspaget Hein W
Abstract excerpt
AIM: To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1, -2, -3, -9, tissue inhibitors of metalloproteinases (TIMP)-1, -2 and tumor necrosis factor (TNF)-alpha in the etiopathogenesis of inflammatory bowel diseases (IBD), that may enhance susceptibility and/or disease severity. METHODS: Genomic DNA from 134 Crohn' s disease (CD), 111...
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