Article
Different HLA class II associations in ulcerative colitis patients with and without primary sclerosing cholangitis.
Genes and immunity - 1 Apr 2007
Karlsen T H, Boberg K M, Vatn M, Bergquist A, Hampe J, Schrumpf E, Thorsby E, Schreiber S, Lie B A
Abstract excerpt
Approximately 80% of patients with primary sclerosing cholangitis (PSC) of Northern European origin have inflammatory bowel disease (IBD), the majority ulcerative colitis (UC). An inherent problem in interpreting positive findings in genetic association studies of PSC is thus to distinguish between factors associated with hepatobiliary versus intestinal pathology. We aimed to clarify to what extent human...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Case-Control Studies
- Child
- Child, Preschool
- Cholangitis, Sclerosing
- Colitis, Ulcerative
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- HLA-DQ Antigens