Article
Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis.
Liver international : official journal of the International Association for the Study of the Liver - 1 Jul 2011
Juran Brian D, Atkinson Elizabeth J, Schlicht Erik M, Larson Joseph J, Ellinghaus David, Franke Andre, Lazaridis Konstantinos N
Abstract excerpt
BACKGROUND: The damaging cholestasis inherent to primary sclerosing cholangitis (PSC) results from bile duct stricturing because of progressive fibrosis. The matrix metalloproteinase 3 (MMP3) degrades a wide range of matrix components and is expressed by activated liver stellate cells, and so is...
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