Article
A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase.
Structure (London, England : 1993) - 4 Mar 2014
Gay Darren C, Gay Glen, Axelrod Abram J, Jenner Matthew, Kohlhaas Christoph, Kampa Annette, Oldham Neil J, Piel Jörn, Keatinge-Clay Adrian T
Abstract excerpt
The recently discovered trans-acyltransferase modular polyketide synthases catalyze the biosynthesis of a wide range of bioactive natural products in bacteria. Here we report the structure of the second ketosynthase from the bacillaene trans-acyltransferase polyketide synthase. This 1.95 Å resolution structure provides the highest resolution view available of a modular polyketide synthase ketosynthase and reveals...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Catalytic Domain
- Crystallography, X-Ray
- Cysteine
- Mass Spectrometry
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Polyketide Synthases