Article
Novel Type III Polyketide Synthases Biosynthesize Methylated Polyketides in Mycobacterium marinum
19 Apr 2018
Abstract excerpt
Mycobacterial pathogenesis is hallmarked by lipidic polyketides that decorate the cell envelope and mediate infection. However, factors mediating persistence remain largely unknown. Dynamic cell wall remodeling could facilitate the different pathogenic phases. Recent studies have implicated type III polyketide synthases (PKSs) in cell wall alterations in several bacteria. Comparative genome analysis revealed...
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