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Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones

7 Oct 2008

Abstract excerpt

BACKGROUND: Mycolactones are immunosuppressive and cytotoxic polyketides, comprising five naturally occurring structural variants (named A/B, C, D, E and F), produced by different species of very closely related mycobacteria including the human pathogen, Mycobacterium ulcerans. In M. ulcerans strain Agy99, mycolactone A/B is produced by three highly homologous type I polyketide megasynthases (PKS), whose genes...

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PMID: 18840298
DOI: 10.1186/1471-2164-9-462

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