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Article

Distinct structural elements dictate the specificity of the type III pentaketide synthase from Neurospora crassa.

Chemistry & biology - 20 Oct 2008

Rubin-Pitel Sheryl B, Zhang Houjin, Vu Trang, Brunzelle Joseph S, Zhao Huimin, Nair Satish K

Abstract excerpt

The fungal type III polyketide synthase 2'-oxoalkylresorcylic acid synthase (ORAS) primes with a range of acyl-Coenzyme A thioesters (C4-C20) and extends using malonyl-Coenzyme A to produce pyrones, resorcinols, and resorcylic acids. To gain insight into this unusual substrate specificity and pro...

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Identifiers

PMID: 18940668
DOI: 10.1016/j.chembiol.2008.08.011
PMCID: PMC2610677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18940668-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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