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Biosynthesis of mycobacterial lipids by polyketide synthases and beyond

14 Mar 2014

Abstract excerpt

Over a decade ago, the analysis of the complete sequence of the genome of the human pathogen Mycobacterium tuberculosis revealed an unexpectedly high number of open reading frames encoding proteins with homology to polyketide synthases (PKSs). PKSs form a large family of fascinating multifunctional enzymes best known for their involvement in the biosynthesis of hundreds of polyketide natural products with diverse...

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PMID: 24625105
DOI: 10.3109/10409238.2014.896859

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