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Article

SREBP-1a polymorphism influences the risk of Alzheimer's disease in carriers of the ApoE4 allele.

Dementia and geriatric cognitive disorders - 1 Jan 2004

Spell Christian, Kölsch Heike, Lütjohann Dieter, Kerksiek Anja, Hentschel Frank, Damian Marinella, von Bergmann Klaus, Rao Marie Luise, Maier Wolfgang, Heun Reinhard

Abstract excerpt

Sterol regulatory element-binding proteins (SREBPs) are transcription factors involved in cholesterol and fatty acid synthesis. Recently, a polymorphism in the 5'-region of the SREBP-1a gene has been described to be correlated with alterations in the plasma levels of cholesterol. Consequently the relationship between this SREBP-1a gene polymorphism and Alzheimer's disease (AD) alone and in combination with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15286454
DOI: 10.1159/000080023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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