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Article

Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease.

International journal of molecular medicine - 1 May 2006

Kölsch Heike, Lütjohann Dieter, Jessen Frank, Von Bergmann Klaus, Schmitz Sandra, Urbach Horst, Maier Wolfgang, Heun Reinhard

Abstract excerpt

The ATP-binding cassette transporter A1 (ABCA1) mediates reverse cholesterol transport, polymorphisms have been shown to influence the levels of cholesterol and of HDL and the risk of coronary artery disease. Since altered cholesterol metabolism is also involved in Alzheimer's disease (AD), the effects of two ABCA1 polymorphisms (G-395C promoter polymorphism (rs 2246293) and exonic R219K) on the risk of AD in 241...

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Identifiers

PMID: 16596262

Genes

ABCA1

Variants

Provenance

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Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease.PMID 16596262Read ↗

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CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk.Semantic proximity Read ↗

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The impact of ABCB1 gene polymorphism (C3435T) and its expression on response to Donepezil in Moroccan patients with Alzheimer's diseaseSemantic proximity Read ↗

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