Article
Diversity considerations in HIV-1 vaccine selection.
Science (New York, N.Y.) - 28 Jun 2002
Gaschen Brian, Taylor Jesse, Yusim Karina, Foley Brian, Gao Feng, Lang Dorothy, Novitsky Vladimir, Haynes Barton, Hahn Beatrice H, Bhattacharya Tanmoy, Korber Bette
Abstract excerpt
Globally, human immunodeficiency virus-type 1 (HIV-1) is extraordinarily variable, and this diversity poses a major obstacle to AIDS vaccine development. Currently, candidate vaccines are derived from isolates, with the hope that they will be sufficiently cross-reactive to protect against circulating viruses. This may be overly optimistic, however, given that HIV-1 envelope proteins can differ in more than 30% of...
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