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Viral sequence diversity: challenges for AIDS vaccine designs

1 Nov 2008

Abstract excerpt

Among the greatest challenges facing AIDS vaccine development is the intrinsic diversity among circulating populations of HIV-1 in various geographical locations and the need to develop vaccines that can elicit enduring protective immunity to variant HIV-1 strains. While variation is observed in all of the viral proteins, the greatest diversity is localized to the viral envelope glycoproteins, evidently...

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PMID: 18980542
DOI: 10.1586/14760584.7.9.1405

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