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Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

29 May 2019

Abstract excerpt

Stabilized HIV-1 envelope glycoproteins (Env) that resemble the native Env are utilized in vaccination strategies aimed at inducing broadly neutralizing antibodies (bNAbs). To limit the exposure of rare isolate-specific antigenic residues/determinants we generated a SOSIP trimer based on a consensus sequence of all HIV-1 group M isolates (ConM). The ConM trimer displays the epitopes of most known bNAbs and...

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PMID: 31142746
DOI: 10.1038/s41467-019-10262-5

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