Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protective efficacy of centralized and polyvalent envelope immunogens in an attenuated equine lentivirus vaccine.

PLoS pathogens - 1 Jan 2015

Craigo Jodi K, Ezzelarab Corin, Cook Sheila J, Liu Chong, Horohov David, Issel Charles J, Montelaro Ronald C

Abstract excerpt

Lentiviral Envelope (Env) antigenic variation and related immune evasion present major hurdles to effective vaccine development. Centralized Env immunogens that minimize the genetic distance between vaccine proteins and circulating viral isolates are an area of increasing study in HIV vaccinology...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigenic Variation
Share to Horses
Share to Infectious Anemia Virus, Equine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phylogeny

Share to Treatment Outcome

Share to Vaccines, Attenuated

Share to Viral Envelope Proteins

Share to Viral Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 25569288
DOI: 10.1371/journal.ppat.1004610
PMCID: PMC4287611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25569288-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protective efficacy of centralized and polyvalent envelope immunogens in an attenuated equine lentivirus vaccine.PMID 25569288Read ↗

Envelope variation as a primary determinant of lentiviral vaccine efficacySemantic proximity Read ↗

EIAV envelope diversity: shaping viral persistence and encumbering vaccine efficacy.Semantic proximity Read ↗

Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity.Semantic proximity Read ↗

Viral sequence diversity: challenges for AIDS vaccine designsSemantic proximity Read ↗

Env diversity-dependent protection of the attenuated equine infectious anaemia virus vaccine.Semantic proximity Read ↗

Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinantsSemantic proximity Read ↗

Lessons in AIDS vaccine development learned from studies of equine infectious, anemia virus infection and immunity.Semantic proximity Read ↗

Genomic comparison between attenuated Chinese equine infectious anemia virus vaccine strains and their parental virulent strains.Semantic proximity Read ↗

Discerning an effective balance between equine infectious anemia virus attenuation and vaccine efficacy.Semantic proximity Read ↗

An EIAV field isolate reveals much higher levels of subtype variability than currently reported for the equine lentivirus family.Semantic proximity Read ↗

Venezuelan equine encephalitis vaccine with rearranged genome resists reversion and protects non-human primates from viremia after aerosol challengeSemantic proximity Read ↗

A Live Attenuated Equine Infectious Anemia Virus Proviral Vaccine with a Modified <i>S2</i> Gene Provides Protection from Detectable Infection by Intravenous Virulent Virus Challenge of Experimentally Inoculated HorsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.