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Article

Challenges in the design of a T cell vaccine in the context of HIV-1 diversity.

Viruses - 23 Oct 2014

Tongo Marcel, Burgers Wendy A

Abstract excerpt

The extraordinary variability of HIV-1 poses a major obstacle to vaccine development. The effectiveness of a vaccine is likely to vary dramatically in different populations infected with different HIV-1 subtypes, unless innovative vaccine immunogens are developed to protect against the range of HIV-1 diversity. Immunogen design for stimulating neutralizing antibody responses focuses on "breadth" - the targeting...

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Identifiers

PMID: 25341662
DOI: 10.3390/v6103968
PMCID: PMC4213573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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