Challenges in the design of a T cell vaccine in the context of HIV-1 diversity.

doi:10.3390/v6103968

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Challenges in the design of a T cell vaccine in the context of HIV-1 diversity.

Viruses - 23 Oct 2014

Tongo Marcel, Burgers Wendy A

Abstract excerpt

The extraordinary variability of HIV-1 poses a major obstacle to vaccine development. The effectiveness of a vaccine is likely to vary dramatically in different populations infected with different HIV-1 subtypes, unless innovative vaccine immunogens are developed to protect against the range of HIV-1 diversity. Immunogen design for stimulating neutralizing antibody responses focuses on "breadth" - the targeting...

Topics

AIDS Vaccines
Antibodies, Neutralizing
Cross Reactions
Gene Products, env
Genetic Variation
HIV Antibodies
HIV Antigens
HIV Infections
HIV-1
Humans
Immunity, Cellular
T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 25341662
DOI: 10.3390/v6103968
PMCID: PMC4213573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics