Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of anti-apoptotic signalling by the insulin receptor and IGF-I receptor in preadipocytes and adipocytes.

Cellular signalling - 1 Apr 2001

Ursø B, Niesler C U, O'Rahilly S, Siddle K

Abstract excerpt

We compared the effectiveness of insulin receptor (IR) and type I insulin-like growth factor (IGF) receptor (IGFR) cytoplasmic domains in mediating anti-apoptotic effects in 3T3-L1 preadipocytes and adipocytes. We used TrkC/IR and TrkC/IGFR chimeras, stably expressed in these cells and stimulated with neurotrophin-3 (NT-3), so as to avoid interference from endogenous receptors. After 24-h serum deprivation, 10%...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Annexin A5
Share to Fluorescein-5-isothiocyanate

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insulin Receptor Substrate Proteins

Share to Nerve Growth Factors

Share to Neurotrophin 3

Share to Receptor, IGF Type 1

Share to Receptor, Insulin

Source

Identifiers

PMID: 11306245
DOI: 10.1016/s0898-6568(01)00130-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparison of anti-apoptotic signalling by the insulin receptor and IGF-I receptor in preadipocytes and adipocytes.PMID 11306245Read ↗

The role of the IGF-I receptor in apoptosis.Semantic proximity Read ↗

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis.Semantic proximity Read ↗

B-raf and insulin synergistically prevent apoptosis and induce cell cycle progression in hematopoietic cells.Semantic proximity Read ↗

The IGF-I/IGF-I Receptor Pathway: Implications in the Pathophysiology of Thyroid CancerSemantic proximity Read ↗

RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death.Semantic proximity Read ↗

IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway.Semantic proximity Read ↗

14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor.Semantic proximity Read ↗

Nucleotide excision repair is not required for the antiapoptotic function of insulin-like growth factor 1.Semantic proximity Read ↗

In vivo regulation of cell death by embryonic (pro)insulin and the insulin receptor during early retinal neurogenesisSemantic proximity Read ↗

Transient activation of Jun N-terminal kinases and protection from apoptosis by the insulin-like growth factor I receptor can be suppressed by dicumarol.Semantic proximity Read ↗

The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase.Semantic proximity Read ↗

Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.