Article
IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1996
Zamorano J, Wang H Y, Wang L M, Pierce J H, Keegan A D
Abstract excerpt
Although it has been known for some time that IL-4 protects cells from death via apoptosis, very little is known about the mechanism by which IL-4 exerts this effect. In this report, we have studied the molecular mechanisms of the IL-4-induced prevention of apoptosis in the 32D and B cell systems...
Topics
- Animals
- Antigens, CD
- Apoptosis
- B-Lymphocytes
- Base Sequence
- Cell Line
- DNA Primers
- Humans
- In Vitro Techniques
- Insulin Receptor Substrate Proteins
- Interleukin-4
- Mice
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphoproteins
- Phosphotransferases (Alcohol Group Acceptor)
- Protein Serine-Threonine Kinases
- Receptors, Interleukin