Article
Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions.
Carcinogenesis - 1 Nov 2004
Lan Qing, Mumford Judy L, Shen Min, Demarini David M, Bonner Matthew R, He Xingzhou, Yeager Meredith, Welch Robert, Chanock Stephen, Tian Linwei, Chapman Robert S, Zheng Tongzhang, Keohavong Phouthone, Caporaso Neil, Rothman Nathaniel
Abstract excerpt
Lung cancer rates among men and particularly among women, almost all of whom are non-smokers, in Xuan Wei County, China are among the highest in China and have been causally associated with exposure to indoor smoky coal emissions that contain very high levels of polycyclic aromatic hydrocarbons (PAHs). As such, this population provides a unique opportunity to study the pathogenesis of PAH-induced lung cancer that...
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