Article
Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China.
International journal of cancer - 20 Sept 2005
Shen Min, Berndt Sonja I, Rothman Nathaniel, Demarini David M, Mumford Judy L, He Xingzhou, Bonner Matthew R, Tian Linwei, Yeager Meredith, Welch Robert, Chanock Stephen, Zheng Tongzhang, Caporaso Neil, Lan Qing
Abstract excerpt
The lung cancer mortality rate in Xuan Wei County is among the highest in China and has been attributed to exposure to indoor smoky coal emissions that contain very high levels of polycyclic aromatic hydrocarbons (PAHs). Nucleotide excision repair (NER) plays a key role in reversing DNA damage from exposure to environmental carcinogens, such as PAHs, that form bulky DNA adducts. We studied single nucleotide...
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