Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer.

doi:10.1016/j.ebiom.2015.04.003

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Article

Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer.

EBioMedicine - 1 Jun 2015

Yu Xian-Jun, Yang Min-Jun, Zhou Bo, Wang Gui-Zhen, Huang Yun-Chao, Wu Li-Chuan, Cheng Xin, Wen Zhe-Sheng, Huang Jin-Yan, Zhang Yun-Dong, Gao Xiao-Hong, Li Gao-Feng, He Shui-Wang, Gu Zhao-Hui, Ma Liang, Pan Chun-Ming, Wang Ping, Chen Hao-Bin, Hong Zhi-Peng, Wang Xiao-Lu, Mao Wen-Jing, Jin Xiao-Long, Kang Hui, Chen Shu-Ting, Zhu Yong-Qiang, Gu Wen-Yi, Liu Zi, Dong Hui, Tian Lin-Wei, Chen Sai-Juan, Cao Yi, Wang Sheng-Yue, Zhou Guang-Biao

Abstract excerpt

Air pollution has been classified as Group 1 carcinogenic to humans, but the underlying tumorigenesis remains unclear. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China attributed to severe air pollution generated by combustion of smoky coal, providing a unique opportunity to dissect lung carcinogenesis of air pollution. Here we analyzed the somatic mutations of 164...

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Identifiers

PMID: 26288819
DOI: 10.1016/j.ebiom.2015.04.003
PMCID: PMC4534757

Genes

RYR2
KRAS
MYH3

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