Associations between 25 lung cancer risk-related SNPs and polycyclic aromatic hydrocarbon-induced genetic damage in coke oven workers.

doi:10.1158/1055-9965.EPI-13-1251

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Article

Associations between 25 lung cancer risk-related SNPs and polycyclic aromatic hydrocarbon-induced genetic damage in coke oven workers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2014

Dai Xiayun, Deng Siyun, Wang Tian, Qiu Gaokun, Li Jun, Yang Binyao, Feng Wei, He Xiaosheng, Deng Qifei, Ye Jian, Zhang Wangzhen, He Meian, Zhang Xiaomin, Guo Huan, Wu Tangchun

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified multiple single-nucleotide polymorphisms (SNP) associated with lung cancer. However, whether these SNPs are associated with genetic damage, a crucial event in cancer initiation and evolution, is still unknown. We aimed to establish associations between these SNPs and genetic damage caused by the ubiquitous carcinogens, polycyclic aromatic...

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PMID: 24692499
DOI: 10.1158/1055-9965.EPI-13-1251

Genes

PAH
BPTF
IMPACT
TERT

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