Article
hOGG1 Ser326Cys and XRCC1 Arg399Gln polymorphisms associated with chronic obstructive pulmonary disease.
Chinese medical journal - 20 Apr 2009
Yang Shi-fang, Xu Yong-jian, Xie Jun-gang, Zhang Zhen-xiang
Abstract excerpt
BACKGROUND: Cigarette-smoke induced DNA damage can cause airway cell apoptosis and death, which may be associated with the development of chronic obstructive pulmonary disease (COPD). However, only 20% - 30% of smokers develop COPD, suggesting that different degrees of DNA repair produce different outcomes in smokers, i.e., part of them develop COPD. We investigated the association between polymorphisms in DNA...
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