Article
Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China.
Anticancer research - 1 Jan 2000
Shen Min, Berndt Sonja I, Rothman Nathaniel, Mumford Judy L, He Xingzhou, Yeager Meredith, Welch Robert, Chanock Stephen, Keohavong Phouthone, Donahue Mark, Zheng Tongzhang, Caporaso Neil, Lan Qing
Abstract excerpt
The lung cancer mortality rate in Xuan Wei is among the highest in China and has been causally attributed to high exposure to indoor smoky coal emissions, which contain high levels of PAHs and can lead to modified bases. We studied genetic polymorphisms in four DNA base excision repair genes in a population-based case-control study in Xuan Wei with 122 lung cancer cases and 122 controls. Homozygous carriers of...
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