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Article

Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion.

Molecular and cellular biology - 1 Aug 2004

Saunders Darren N, Hird Samantha L, Withington Sarah L, Dunwoodie Sally L, Henderson Michelle J, Biben Christine, Sutherland Robert L, Ormandy Christopher J, Watts Colin K W

Abstract excerpt

EDD is the mammalian ortholog of the Drosophila melanogaster hyperplastic disc gene (hyd), which is critical for cell proliferation and differentiation in flies through regulation of hedgehog and decapentaplegic signaling. Amplification and overexpression of EDD occurs frequently in several cancers, including those of the breast and ovary, and truncating mutations of EDD are also observed in gastric and colon...

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Identifiers

PMID: 15282321
DOI: 10.1128/MCB.24.16.7225-7234.2004
PMCID: PMC479729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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