Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo.

PloS one - 1 Jan 2013

Tanaka Satomi S, Nakane Akihiro, Yamaguchi Yasuka L, Terabayashi Takeshi, Abe Takaya, Nakao Kazuki, Asashima Makoto, Steiner Kirsten A, Tam Patrick P L, Nishinakamura Ryuichi

Abstract excerpt

Dullard/Ctdnep1 is a member of the serine/threonine phosphatase family of the C-terminal domain of eukaryotic RNA polymerase II. Embryos lacking Dullard activity fail to form primordial germ cells (PGCs). In the mouse, the formation of PGCs is influenced by BMP4 and WNT3 activity. Although Dullard is reputed to negatively regulate BMP receptor function, in this study we found mutations in Dullard had no...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Bone Morphogenetic Protein 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dishevelled Proteins

Share to Germ Cells

Share to Morphogenesis

Share to Phosphoprotein Phosphatases

Share to Smad Proteins

Share to Wnt3 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 23469192
DOI: 10.1371/journal.pone.0057428
PMCID: PMC3587611

Genes

BMP4
PGC
WNT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo.PMID 23469192Read ↗

Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction.Semantic proximity Read ↗

Loss of Dact1 Disrupts Planar Cell Polarity Signaling by Altering Dishevelled Activity and Leads to Posterior Malformation in MiceSemantic proximity Read ↗

The tumor suppressor PRDM5 regulates Wnt signaling at early stages of zebrafish development.Semantic proximity Read ↗

Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell developmentSemantic proximity Read ↗

Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion.Semantic proximity Read ↗

Negative modulation of bone morphogenetic protein signaling by Dullard during wing vein formation in Drosophila.Semantic proximity Read ↗

Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skinSemantic proximity Read ↗

Discs large 5, an Essential Gene in Drosophila, Regulates Egg Chamber Organization.Semantic proximity Read ↗

A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation.Semantic proximity Read ↗

ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development.Semantic proximity Read ↗

Quantitative analysis of signaling responses during mouse primordial germ cell specificationSemantic proximity Read ↗

Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.