Article
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Nature - 20 Jun 2013
Rivkin Elena, Almeida Stephanie M, Ceccarelli Derek F, Juang Yu-Chi, MacLean Teresa A, Srikumar Tharan, Huang Hao, Dunham Wade H, Fukumura Ryutaro, Xie Gang, Gondo Yoichi, Raught Brian, Gingras Anne-Claude, Sicheri Frank, Cordes Sabine P
Abstract excerpt
A complex interaction of signalling events, including the Wnt pathway, regulates sprouting of blood vessels from pre-existing vasculature during angiogenesis. Here we show that two distinct mutations in the (uro)chordate-specific gumby (also called Fam105b) gene cause an embryonic angiogenic phenotype in gumby mice. Gumby interacts with disheveled 2 (DVL2), is expressed in canonical Wnt-responsive endothelial...
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