Predisposition to cancer caused by genetic and functional defects of mammalian Atad5.

doi:10.1371/journal.pgen.1002245

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Predisposition to cancer caused by genetic and functional defects of mammalian Atad5.

PLoS genetics - 1 Aug 2011

Bell Daphne W, Sikdar Nilabja, Lee Kyoo-Young, Price Jessica C, Chatterjee Raghunath, Park Hee-Dong, Fox Jennifer, Ishiai Masamichi, Rudd Meghan L, Pollock Lana M, Fogoros Sarah K, Mohamed Hassan, Hanigan Christin L, Zhang Suiyuan, Cruz Pedro, Renaud Gabriel, Hansen Nancy F, Cherukuri Praveen F, Borate Bhavesh, McManus Kirk J, Stoepel Jan, Sipahimalani Payal, Godwin Andrew K, Sgroi Dennis C, Merino Maria J, Elliot Gene, Elkahloun Abdel, Vinson Charles, Takata Minoru, Mullikin James C, Wolfsberg Tyra G, Hieter Philip, Lim Dae-Sik, Myung Kyungjae

Abstract excerpt

ATAD5, the human ortholog of yeast Elg1, plays a role in PCNA deubiquitination. Since PCNA modification is important to regulate DNA damage bypass, ATAD5 may be important for suppression of genomic instability in mammals in vivo. To test this hypothesis, we generated heterozygous (Atad5(+/m)) mice that were haploinsuffficient for Atad5. Atad5(+/m) mice displayed high levels of genomic instability in vivo, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aneuploidy

Share to ATPases Associated with Diverse Cellular Activities

Share to Cell Transformation, Neoplastic

Share to Endometrial Neoplasms

Share to Genomic Instability

Share to Proliferating Cell Nuclear Antigen

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 21901109
DOI: 10.1371/journal.pgen.1002245
PMCID: PMC3161924

Genes

ATAD5
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Predisposition to cancer caused by genetic and functional defects of mammalian Atad5.PMID 21901109Read ↗

Rare ATAD5 missense variants in breast and ovarian cancer patients.Semantic proximity Read ↗

GCN5: a supervisor in all-inclusive control of vertebrate cell cycle progression through transcription regulation of various cell cycle-related genes.Semantic proximity Read ↗

Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion.Semantic proximity Read ↗

Cullin 3 targets the tumor suppressor gene ARMC5 for ubiquitination and degradationSemantic proximity Read ↗

Armc5 deletion causes developmental defects and compromises T-cell immune responses.Semantic proximity Read ↗

Genomic Mutations of the STAT5 Transcription Factor Are Associated with Human Cancer and Immune Diseases.Semantic proximity Read ↗

Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo.Semantic proximity Read ↗

Uncovering the dosage-dependent roles of Arid1a in gastric tumorigenesis for combinatorial drug therapySemantic proximity Read ↗

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic CancerSemantic proximity Read ↗

The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic TransformationSemantic proximity Read ↗

Genomic alterations and abnormal expression of APE2 in multiple cancersSemantic proximity Read ↗

Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.